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Literature summary for 2.7.11.21 extracted from

  • Matsumura, S.; Toyoshima, F.; Nishida, E.
    Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1 (2007), J. Biol. Chem., 282, 15217-15227.
    View publication on PubMed
Search for more literature for 2.7.11.21

Application

Application Comment Organism
additional information Plk1 facilitates chromosome alignment during prometaphase through BubR1, Plk1 is necessary for not only proper spindle assembly but also the formation of functional kinetochore-microtubule attachments Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
synchronized HeLa GFP-histone H2B cells transfected with HA-tagged mouse Plk1 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
RNAi down-regulation of Plk1 protein level by ca. 90%, abolishes the mobility-shifted, hyperphosphorylated form of BubR1 in the prometaphase-arrested cells Homo sapiens
RNAi specific down-regulation of Plk1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore BubR1 colocalizes with Plk1 at kinetochores of unaligned chromosomes Homo sapiens 776
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
HeLa GFP-histone H2B cell
-
 Homo sapiens
-
HeLa-S3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + BubR1 BubR1 interacts with Plk1 during prometaphase, binds to the C-terminal, complete polo-box domain of Plk1 Homo sapiens ADP + phosphorylated BubR1
-
 ?
ATP + BubR1 Plk1 is responsible for the hyperphosphorylation of BubR1 during prometaphase Mus musculus ADP + phosphorylated BubR1
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
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 Mus musculus
Plk1
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 Homo sapiens
Polo-like kinase 1
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 Mus musculus
Polo-like kinase 1
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 Homo sapiens