Application | Comment | Organism |
---|---|---|
additional information | Plk1 has specific functions in Emi1 degradation, activation of Cdk1-cyclin B, cohesin release, centrosome function, and regulation of microtubule-kinetochore attachments, Plk1 is not required for prophase entry, but is required for timely entry into prometaphase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BI 2536 | potent and selective inhibitor of Plk1, delays prophase and entrance into prometaphase, initiates cyclin A destruction without degrading Emi1, leads to spindle-assembly-checkpoint-induced prometaphase arrest, prevents Plk1s enrichment at kinetochores and centrosomes, in metaphase cells induces detachment of microtubules from kinetochores and leads to spindle collapse, the inhibitor may serve as a powerful tool in mitosis research | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
centrosome | - |
Homo sapiens | 5813 | - |
centrosome | Plk1s accumulation depends on its own activity, activity is required for maintaining centrosome function | Homo sapiens | 5813 | - |
kinetochore | - |
Homo sapiens | 776 | - |
kinetochore | Plk1s accumulation depends on its own activity, activity is required for maintaining kinetochore function | Homo sapiens | 776 | - |
spindle | - |
Homo sapiens | 5819 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | Homo sapiens | - |
ADP + phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdc25C | - |
Homo sapiens | ADP + phosphorylated Cdc25C | - |
? | |
ATP + protein | - |
Homo sapiens | ADP + phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000083 | - |
- |
Homo sapiens | BI 2536 |