Application | Comment | Organism |
---|---|---|
medicine | Plk1 is a target for the development of anticancer therapeutics | Homo sapiens |
additional information | RhoA and Plk1 physically interact, their interaction appears to be enhanced during mitosis, Plk1 may alter activation of RhoA during mitotic cytokinesis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
kinetochore | localizes to kinetochores during prophase and metaphase | Homo sapiens | 776 | - |
additional information | translocates to the midbody during telophase, RhoA is also enriched at the midbody region during telophase and colocalizes with Plk1 | Homo sapiens | - |
- |
spindle | - |
Homo sapiens | 5819 | - |
spindle | localizes to spindle poles during prophase and metaphase | Homo sapiens | 5819 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | Homo sapiens | - |
ADP + phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P53350 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | - |
Homo sapiens | ADP + phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |