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Literature summary for 2.7.11.21 extracted from

  • Dai, B.N.; Yang, Y.; Chau, Z.; Jhanwar-Uniyal, M.
    Polo-like kinase 1 regulates RhoA during cytokinesis exit in human cells (2007), Cell Prolif., 40, 550-557.
    View publication on PubMed

Application

Application Comment Organism
medicine Plk1 is a target for the development of anticancer therapeutics Homo sapiens
additional information RhoA and Plk1 physically interact, their interaction appears to be enhanced during mitosis, Plk1 may alter activation of RhoA during mitotic cytokinesis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore localizes to kinetochores during prophase and metaphase Homo sapiens 776
-
additional information translocates to the midbody during telophase, RhoA is also enriched at the midbody region during telophase and colocalizes with Plk1 Homo sapiens
-
-
spindle
-
Homo sapiens 5819
-
spindle localizes to spindle poles during prophase and metaphase Homo sapiens 5819
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens
-
ADP + phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein
-
Homo sapiens ADP + phosphoprotein
-
?

Synonyms

Synonyms Comment Organism
Plk1
-
Homo sapiens
Polo-like kinase 1
-
Homo sapiens