Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.21 extracted from

  • Liu, X.; Erikson, R.L.
    Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells (2003), Proc. Natl. Acad. Sci. USA, 100, 5789-5794.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of Plk1 in HeLa cells, DU145 cells, T98G cells, and in GM05849 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme depletion using the vector-based small interfering RNA technique, Plk1 depletion leads to highly inhibited cell proliferation, decreased viability, and results in cell-cycle arrest with 4 n DNA content, formation of dumbbell-like chromatin structure due to impaired sister chromatin separation, induction of apoptosis, the apoptotic effect is reversible by co-transfection of murine Plk1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Plk1 depletion induces apoptosis in cancer cells and stabilizes p53 tumor-suppressor protein ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Plk1 depletion induces apoptosis in cancer cells and stabilizes p53 tumor-suppressor protein Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Plk1
-
Homo sapiens
Polo-like kinase 1
-
Homo sapiens