Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in vivo enzyme activity is dependent on Cut12 | Schizosaccharomyces pombe |
Protein Variants | Comment | Organism |
---|---|---|
E139K | site-directed mutagenesis, mutation in the kinase domain, mutant enzyme is fully active with histone H1 kinase | Schizosaccharomyces pombe |
additional information | generation of temperature-sensitive mutants of Plo1 which are inactivated at 35°C for 4 h, Plo1 activity is abolished in Cut12 loss-of-function mutant cells, but is increased in Cut12 gain-of-function mutant cells | Schizosaccharomyces pombe |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
spindle pole | - |
Schizosaccharomyces pombe | 922 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Schizosaccharomyces pombe | physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment by feedback control of the MPF complex, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schizosaccharomyces pombe | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 kinase | activation | Schizosaccharomyces pombe | ADP + phosphorylated histone H1 kinase | - |
? | |
additional information | physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment by feedback control of the MPF complex, overview | Schizosaccharomyces pombe | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plo1 | - |
Schizosaccharomyces pombe |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Schizosaccharomyces pombe |