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Literature summary for 2.7.11.21 extracted from

  • MacIver, F.H.; Tanaka, K.; Robertson, A.M.; Hagan, I.M.
    Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe (2003), Genes Dev., 17, 1507-1523.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information in vivo enzyme activity is dependent on Cut12 Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
E139K site-directed mutagenesis, mutation in the kinase domain, mutant enzyme is fully active with histone H1 kinase Schizosaccharomyces pombe
additional information generation of temperature-sensitive mutants of Plo1 which are inactivated at 35°C for 4 h, Plo1 activity is abolished in Cut12 loss-of-function mutant cells, but is increased in Cut12 gain-of-function mutant cells Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining
spindle pole
-
Schizosaccharomyces pombe 922
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Schizosaccharomyces pombe physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment by feedback control of the MPF complex, overview ?
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?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1 kinase activation Schizosaccharomyces pombe ADP + phosphorylated histone H1 kinase
-
?
additional information physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment by feedback control of the MPF complex, overview Schizosaccharomyces pombe ?
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?

Synonyms

Synonyms Comment Organism
Plo1
-
Schizosaccharomyces pombe

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Schizosaccharomyces pombe