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Literature summary for 2.7.11.20 extracted from
- GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice (2013), Lab. Invest., 93, 303-310.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activated by incubation with histidine-free medium | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylated GCN2 is the active form of the enzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatic stellate cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCN2 | - |
Mus musculus |
| GCN2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in vivo studies with Gcn2 knockout mice show increased susceptibility to both acute or chronic liver damage induced by CCl4, as shown by higher alanine aminotransferase and aspartate aminotransferase activities, increased necrosis and higher inflammatory infiltrates compared with wild-type mice. Chronic CCl4 treatment increases deposition of interstitial collagen type I. Col1a1 and col1a2 mRNA levels also increase in CCl4-treated Gcn2-/- mice compared with wild-type mice | Mus musculus |
| physiological function | the enzyme has a key role in collagen type I production by hepatic stellate cells | Homo sapiens |
| physiological function | the enzyme is a key regulator of the fibrogenic response to liver injury | Mus musculus |
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