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Literature summary for 2.7.11.20 extracted from

  • Rose, A.J.; Alsted, T.J.; Jensen, T.E.; Kobber?, J.B.; Maarbjerg, S.J.; Jensen, J.; Richter, E.A.
    A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions (2009), J. Physiol., 587, 1547-1563.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-3-cetyl-2-methylimidazolium iodide NH125 Rattus norvegicus
2-((3,5-di-tert-butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione TX-1123 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 2] Rattus norvegicus
-
 ADP + [elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Sprague-Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 2]
-
 Rattus norvegicus ADP + [elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Rattus norvegicus
eEF2K
-
 Rattus norvegicus
eukaryotic elongation factor 2 kinase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 activity assay Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.8 7.2
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus