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Literature summary for 2.7.11.20 extracted from

  • Sataranatarajan, K.; Mariappan, M.M.; Lee, M.J.; Feliers, D.; Choudhury, G.G.; Barnes, J.L.; Kasinath, B.S.
    Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin (2007), Am. J. Pathol., 171, 1733-1742.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
D-glucose high glucose or high insulin rapidly increase inactivating Ser366 phosphorylation of eEF2 kinase Mus musculus
Insulin high glucose or high insulin rapidly increase inactivating Ser366 phosphorylation of eEF2 kinase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic translation elongation factor 2] Mus musculus high glucose and high insulin regulate phosphorylation of eEF2 and eEF2 kinase by rapidly increasing activating Thr56 dephosphorylation of eEF2 and inactivating Ser366 phosphorylation of eEF2 kinase, events that facilitate elongation, overview ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BLKsJ lepr-/-db/db mice, diabetc mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein inactivating Ser366 phosphorylation of eEF2 kinase Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation phosphorylated or dephosphorylated enzyme Mus musculus
-
renal cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic translation elongation factor 2] phosphorylation at Thr56 Mus musculus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
ATP + [eukaryotic translation elongation factor 2] high glucose and high insulin regulate phosphorylation of eEF2 and eEF2 kinase by rapidly increasing activating Thr56 dephosphorylation of eEF2 and inactivating Ser366 phosphorylation of eEF2 kinase, events that facilitate elongation, overview Mus musculus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Mus musculus