Activating Compound | Comment | Organism | Structure |
---|---|---|---|
MG132 | addition to normoxic MCF10A cells results in a 5- to 10fold increase in eEF2K levels but has no effect on hypoxic MCF10A or HTB20 cells | Homo sapiens | |
additional information | increased eEF2 phosphorylation in hypoxic MCF10A cells is associated with a 5- to 10fold increase in eEF2K protein levels without an increase in eEF2K mRNA levels | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | eEF2 kinase is stabilized against decay during hypoxia by phosphorylation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | eEF2K can be directly inhibited by mTOR phosphorylation and indirectly inhibited by mTOR through p70S6k phosphorylation | Homo sapiens | |
shRNA | eEF2K protein levels are 8fold reduced | Homo sapiens | |
siRNA | eEF2K protein levels are decreased ca. 90% in cells transfected with eEF2K siRNA and unaltered by NS siRNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-474 cell | - |
Homo sapiens | - |
BT-483 cell | - |
Homo sapiens | - |
HCC-1395 cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-175-VII cell | - |
Homo sapiens | - |
UACC-893 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Homo sapiens |
eukaryotic elongation factor 2 kinase | - |
Homo sapiens |