Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is activated by uncharged tRNA-dependent mechanisms | Mus musculus |
Application | Comment | Organism |
---|---|---|
additional information | novel function of GCN2, regulates lipid metabolism during leucine deprivation in addition to regulating amino acid metabolism | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GCN2-deficient mice fed a leucine-deprived diet, develop liver steatosis, genes related to triglyceride synthesis and expression of SREBP-1c and PPARg are not repressed. Beta-oxidation genes and fatty-acid transport genes are upregulated, mutant exhibits reduced lipid mobilization | Mus musculus |
additional information | construction of Gcn2 knockout mice and effects on enzyme activity and leucine metabolism, phenotype, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | Mus musculus | the reaction leads to derepression of transcription factor GCN4 | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | Mus musculus C57/BL6J | the reaction leads to derepression of transcription factor GCN4 | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
additional information | Mus musculus | the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview | ? | - |
? | |
additional information | Mus musculus C57/BL6J | the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | expression of lipogenic genes and the activity of fatty acid synthase in the liver are repressed and lipid stores in adipose tissue are mobilized in GCN2 wild-type mice upon leucine deprivation | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | - |
Mus musculus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | the reaction leads to derepression of transcription factor GCN4 | Mus musculus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | - |
Mus musculus C57/BL6J | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | the reaction leads to derepression of transcription factor GCN4 | Mus musculus C57/BL6J | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
additional information | the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview | Mus musculus | ? | - |
? | |
additional information | the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview | Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCN2 | - |
Mus musculus |
GCN2 eIF2alpha kinase | - |
Mus musculus |
GCN2 kinase | - |
Mus musculus |
general control nonderepressible 2 kinase | - |
Mus musculus |