Literature summary for 2.7.11.20 extracted from

Hait, W.N.; Wu, H.; Jin, S.; Yang, J.M.
Elongation factor-2 kinase: its role in protein synthesis and autophagy (2006), Autophagy, 2, 294-296.

Search for more literature for 2.7.11.20

Application

Application	Comment	Organism
medicine	plays a regulatory role in the autophagic process in tumor cells and may promote cancer cell survival under conditions of nutrient deprivation, eEF-2 kinase activation may be a part of a survival mechanism in glioblastoma	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	knockdown of eEF-2 kinase and inhibition of autophagy in several cell types	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	when deprived of nutrients, the activity of eEF-2 kinase is rapidly increased	Homo sapiens	-
T-98G cell	when deprived of nutrients, the activity of eEF-2 kinase is rapidly increased	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [elongation factor 2]	-	Homo sapiens	ADP + [elongation factor 2]phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Ca2+/calmodulin-dependent kinase III	-	Homo sapiens
eEF-2 kinase	-	Homo sapiens

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Release 2023.1 (January 2023)