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Literature summary for 2.7.11.20 extracted from

  • Carroll, M.; Warren, O.; Fan, X.; Sossin, W.S.
    5-HT stimulates eEF2 dephosphorylation in a rapamycin-sensitive manner in Aplysia neurites (2004), J. Neurochem., 90, 1464-1476.
    View publication on PubMed
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
5-hydroxytryptamine rapamycin activates the enzyme in neuron and antagonizes serotonin mediated by 5-hydroxytryptamine, rapamycin alone has no effect, but increases with 5-hydroxytryptamine the dephosphorylation of the eukaryotic elongation factor 2, 5-hydroxytryptamine decreases the phosphorylation of the eukaryotic elongation factor 2 at Thr57 in a rapamycin-sensitive manner, mechanism Aplysia californica
Rapamycin rapamycin activates the enzyme in neuron and antagonizes serotonin mediated by 5-hydroxytryptamine, rapamycin alone has no effect, but increases with 5-hydroxytryptamine the dephosphorylation of the eukaryotic elongation factor 2, 5-hydroxytryptamine decreases the phosphorylation of the eukaryotic elongation factor 2 at Thr57 in a rapamycin-sensitive manner, mechanism Aplysia californica

Inhibitors

Inhibitors Comment Organism Structure
serotonin inhibits the enzyme in synaptosomes and in isolated neurites, antagonizes rapamycin/5-hydroxytryptamine, mechanism Aplysia californica

Localization

Localization Comment Organism GeneOntology No. Textmining
synaptosome
-
 Aplysia californica
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-dependent elongation factor 2 phosphorylation and inhibition blocks the elongation in translation, rapamycin/5-hydroxytryptamine increase the dephosphorylation Aplysia californica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 2] Aplysia californica phosphorylation at Thr57 inhibits the elongation factor 2 and blocks translational elongation, enzyme activity is regulated by rampamycin, 5-hydroxytryptamine, and serotonin, regulation mechanism ADP + [elongation factor 2]phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Aplysia californica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Aplysia californica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 2] phosphorylation at Thr57 inhibits the elongation factor 2 and blocks translational elongation, enzyme activity is regulated by rampamycin, 5-hydroxytryptamine, and serotonin, regulation mechanism Aplysia californica ADP + [elongation factor 2]phosphate
-
 ?
ATP + [elongation factor 2] phosphorylation at Thr57 inhibits the elongation factor 2 Aplysia californica ADP + [elongation factor 2]phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eEF-2 kinase
-
 Aplysia californica
eukaryotic elongation factor 2 kinase
-
 Aplysia californica

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Aplysia californica