Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GCN1-GCN20 | positive effectors, uncharged tRNAs activate GCN2 requiring direct interaction with both the GCN1-GCN20 regulatory complex and ribosomes | Saccharomyces cerevisiae | |
additional information | the eEF3-like domain has an effector function in GCN2 activation | Saccharomyces cerevisiae | |
uncharged tRNAs | activate GCN2 requiring direct interaction with both the GCN1-GCN20 regulatory complex and ribosomes | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of GCN1 and GCN2 mutants with mutations in the domain structures that are involved in interaction between the GCNs, the elongation factors, and the polyribosome, overview | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 3] | Saccharomyces cerevisiae | - |
ADP + [elongation factor 3]phosphate | - |
? | |
ATP + [eukaryotic translation initiation factor 2alpha] | Saccharomyces cerevisiae | GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview | ADP + [eukaryotic translation initiation factor 2alpha]phosphate | - |
? | |
additional information | Saccharomyces cerevisiae | translation regulation mechanism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 3] | - |
Saccharomyces cerevisiae | ADP + [elongation factor 3]phosphate | - |
? | |
ATP + [eukaryotic translation initiation factor 2alpha] | - |
Saccharomyces cerevisiae | ADP + [eukaryotic translation initiation factor 2alpha]phosphate | - |
? | |
ATP + [eukaryotic translation initiation factor 2alpha] | GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview | Saccharomyces cerevisiae | ADP + [eukaryotic translation initiation factor 2alpha]phosphate | - |
? | |
additional information | translation regulation mechanism | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eukaryotic translation initiation factor 2alpha kinase | - |
Saccharomyces cerevisiae |
GCN2 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |