Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.20 extracted from

  • Sattlegger, E.; Hinnebusch, A.G.
    Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation (2005), J. Biol. Chem., 280, 16514-16521.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
GCN1-GCN20 positive effectors, uncharged tRNAs activate GCN2 requiring direct interaction with both the GCN1-GCN20 regulatory complex and ribosomes Saccharomyces cerevisiae
additional information the eEF3-like domain has an effector function in GCN2 activation Saccharomyces cerevisiae
uncharged tRNAs activate GCN2 requiring direct interaction with both the GCN1-GCN20 regulatory complex and ribosomes Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information construction of GCN1 and GCN2 mutants with mutations in the domain structures that are involved in interaction between the GCNs, the elongation factors, and the polyribosome, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 3] Saccharomyces cerevisiae
-
ADP + [elongation factor 3]phosphate
-
?
ATP + [eukaryotic translation initiation factor 2alpha] Saccharomyces cerevisiae GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
?
additional information Saccharomyces cerevisiae translation regulation mechanism ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 3]
-
Saccharomyces cerevisiae ADP + [elongation factor 3]phosphate
-
?
ATP + [eukaryotic translation initiation factor 2alpha]
-
Saccharomyces cerevisiae ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
?
ATP + [eukaryotic translation initiation factor 2alpha] GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview Saccharomyces cerevisiae ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
?
additional information translation regulation mechanism Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
eukaryotic translation initiation factor 2alpha kinase
-
Saccharomyces cerevisiae
GCN2
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Saccharomyces cerevisiae