General Stability | Organism |
---|---|
in vivo half-life of the enzyme is 6 h, proteasome inhibitor MG132 prolonged the half-life of the enzyme to more than 24 h | Homo sapiens |
in vivo half-life of the enzyme is 6 h, proteasome inhibitor MG132 prolonged the half-life of the enzyme to more than 24 h | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Homo sapiens | - |
ADP + [elongation factor 2]phosphate | - |
? | |
ATP + [elongation factor 2] | Rattus norvegicus | - |
ADP + [elongation factor 2]phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | the enzyme is ubiquitinated in vivo, ubiquitination and turnover is increased by inhibition of heat shock protein 90, enzyme degradation involves the proteasome | Homo sapiens |
additional information | the enzyme is ubiquitinated in vivo, ubiquitination and turnover is increased by inhibition of heat shock protein 90, enzyme degradation involves the proteasome | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | ovarian carcinoma cell line | Homo sapiens | - |
glioma cell line | C-6 cell, half-life of the enzyme is 6 h | Rattus norvegicus | - |
MCF-7 cell | breastcancer cell line | Homo sapiens | - |
T-98G cell | glioma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | - |
Homo sapiens | ADP + [elongation factor 2]phosphate | - |
? | |
ATP + [elongation factor 2] | - |
Rattus norvegicus | ADP + [elongation factor 2]phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF-2 kinase | - |
Homo sapiens |
eEF-2 kinase | - |
Rattus norvegicus |
eukaryotic elongation factor 2 kinase | - |
Rattus norvegicus |
eukaryotic elongation factor-2 kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |