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Literature summary for 2.7.11.20 extracted from
- Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase (2005), Cancer Res., 65, 3806-3810.
General Stability
| General Stability | Organism |
|---|---|
| in vivo half-life of the enzyme is 6 h, proteasome inhibitor MG132 prolonged the half-life of the enzyme to more than 24 h | Homo sapiens |
| in vivo half-life of the enzyme is 6 h, proteasome inhibitor MG132 prolonged the half-life of the enzyme to more than 24 h | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [elongation factor 2] | Homo sapiens | - |
ADP + [elongation factor 2]phosphate | - |
? |  |
| ATP + [elongation factor 2] | Rattus norvegicus | - |
ADP + [elongation factor 2]phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | the enzyme is ubiquitinated in vivo, ubiquitination and turnover is increased by inhibition of heat shock protein 90, enzyme degradation involves the proteasome | Homo sapiens |
| additional information | the enzyme is ubiquitinated in vivo, ubiquitination and turnover is increased by inhibition of heat shock protein 90, enzyme degradation involves the proteasome | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-2780 cell | ovarian carcinoma cell line | Homo sapiens | - |
| glioma cell line | C-6 cell, half-life of the enzyme is 6 h | Rattus norvegicus | - |
| MCF-7 cell | breastcancer cell line | Homo sapiens | - |
| T-98G cell | glioma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [elongation factor 2] | - |
Homo sapiens | ADP + [elongation factor 2]phosphate | - |
? | |
| ATP + [elongation factor 2] | - |
Rattus norvegicus | ADP + [elongation factor 2]phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eEF-2 kinase | - |
Homo sapiens |
| eEF-2 kinase | - |
Rattus norvegicus |
| eukaryotic elongation factor 2 kinase | - |
Rattus norvegicus |
| eukaryotic elongation factor-2 kinase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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