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Literature summary for 2.7.11.2 extracted from

  • Ma, K.; Zhang, Y.; Elam, M.B.; Cook, G.A.; Park, E.A.
    Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator (2005), J. Biol. Chem., 280, 29525-29532.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information PDK4 expression is induced by hepatic nuclear factor 4, HNF4, determination of binding sites on the PDK4 promoter Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis of the PDK4 gene promoter, analysis of transcriptional activation mechanism, expression analysis, overview, transient expression of PDK4 promoter mutants in hepatocytes Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of PDK4 gene promoter deletion and point mutants for functional analysis, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate dehydrogenase Rattus norvegicus phosphorylation by PDK inhibits the pyruvate dehydrogenase complex, PDK plays a regulatory role in glucose metabolism, PDK4 expression is regulated by hepatic nuclear factor 4 and peroxisome proliferator-activated receptor gamma coactivator, PGC-1alpha ADP + phosphorylated pyruvate dehydrogenase
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Rattus norvegicus
-
liver
-
Rattus norvegicus
-
myocyte cardiac Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate dehydrogenase
-
Rattus norvegicus ADP + phosphorylated pyruvate dehydrogenase
-
?
ATP + pyruvate dehydrogenase phosphorylation by PDK inhibits the pyruvate dehydrogenase complex, PDK plays a regulatory role in glucose metabolism, PDK4 expression is regulated by hepatic nuclear factor 4 and peroxisome proliferator-activated receptor gamma coactivator, PGC-1alpha Rattus norvegicus ADP + phosphorylated pyruvate dehydrogenase
-
?

Synonyms

Synonyms Comment Organism
PDK4
-
Rattus norvegicus
pyruvate dehydrogenase kinase 4
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus