Literature summary for 2.7.11.2 extracted from

Watt, M.J.; Heigenhauser, G.J.; LeBlanc, P.J.; Inglis, J.G.; Spriet, L.L.; Peters, S.J.
Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise (2004), J. Appl. Physiol., 97, 1261-1267.

Search for more literature for 2.7.11.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	rapid upregulation of isozyme PDK4 in skeletal muscle after prolonged exercise, PDK activity is increased 2.5fold during 240 min of exercise	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + pyruvate dehydrogenase	Homo sapiens	-	ADP + phosphorylated pyruvate dehydrogenase	-	?
additional information	Homo sapiens	rapid upregulation of isozyme PDK4 in skeletal muscle after prolonged exercise, PDK activity is increased during prolonged exercise, physiologic/metabolic state, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoyzmes PDK-2 and PDK-4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + pyruvate dehydrogenase	-	Homo sapiens	ADP + phosphorylated pyruvate dehydrogenase	-	?
additional information	rapid upregulation of isozyme PDK4 in skeletal muscle after prolonged exercise, PDK activity is increased during prolonged exercise, physiologic/metabolic state, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PDK	-	Homo sapiens
PDK-2	-	Homo sapiens
PDK-4	-	Homo sapiens
pyruvate dehydrogenase kinase	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0014	-	pyruvate dehydrogenase	PDK activity in skeletal muscle after short 10 min or no exercise	Homo sapiens
0.0032	-	pyruvate dehydrogenase	PDK activity in skeletal muscle after prolonged exercise of 240 min	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)