Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | agonist activation of peroxisome proliferator-activated receptors alpha and delta specifically upregulates PDK4 transcription, while activation of peroxisome proliferator-activated receptor gamma specifically downregulates PDK2 transcription, reduced glucose levels increase expression levels of PDK2 and PDK4, the stimulation effect is reversed by insulin, insulin alone decreases the enzyme expression levels below basal values | Homo sapiens | |
oleate | activates PDK2 and PDK4 nearly 2fold at 0.1 mM, not synergistic with palmitate, stimulation is completely inhibited by insulin at 0.001 mM | Homo sapiens | |
palmitate | activates PDK2 and PDK4 nearly 2fold at 0.1 mM, not synergistic with oleate, stimulation is completely inhibited by insulin at 0.001 mmM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression analysis and mRNA level determination for isozymes PDK2 and PDK4 in response to several effectors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | insulin reverses the stimulation effect of reduced glucose levels increasing expression levels of PDK2 and PDK4, insulin alone decreases the enzyme expression levels below basal values, insulin effects on the enzyme are inhibited by phosphoatidyl 3-kinase inhibitors wortmannin and LY294002, i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Homo sapiens | |
Rapamycin | inhibits PDK2 and PDK4, has no effect on insulin-caused downregulation of the isozymes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | peroxisome proliferator-activated receptors and insulin have regulatory functions in expression of isozymes PDK2 and PDK4, regulation mechanism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes PDK1-4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Homo sapiens | - |
muscle cell | - |
Homo sapiens | - |
myoblast | - |
Homo sapiens | - |
myotube | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | peroxisome proliferator-activated receptors and insulin have regulatory functions in expression of isozymes PDK2 and PDK4, regulation mechanism | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDK1 | - |
Homo sapiens |
PDK2 | - |
Homo sapiens |
PDK3 | - |
Homo sapiens |
PDK4 | - |
Homo sapiens |
pyruvate dehydrogenase kinase | - |
Homo sapiens |