Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Lipid | enhance expression of hepatic isozyme PDK2 during high-fat feeding | Rattus norvegicus | |
additional information | during hyperthyroidism, the expression of hepatic isozymes PDK2 and PDK4 is increased | Rattus norvegicus | |
additional information | starvation increases expression of isozyme PDK4 | Rattus norvegicus | |
peroxisome proliferator-activated receptor-alpha | involved in mechanism to enhance expression of isozyme PDK4, but not isozyme PDK2, during starvation | Rattus norvegicus | |
WY-14,643 | activator of peroxisome proliferator-activated receptor-alpha | Rattus norvegicus | |
WY-14,643 | in liver, specifically increases PDK4 expression | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | Rattus norvegicus | tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | Rattus norvegicus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | Rattus norvegicus | high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female Wistar rats | - |
Rattus norvegicus | - |
isozymes PDK2 and PDK4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | a complex signalling mechanism mediates the regulation of the isozymes PDK2 and PDK4 in response to the feeding status of the organism, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | - |
Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption | Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications | Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
PDK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Rattus norvegicus |