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Literature summary for 2.7.11.19 extracted from

  • Sul, H.S.; Dirden, B.; Angelos, K.L.; Hallenbeck, P.; Walsh, D.
    Cardiac phosphorylase kinase: preparation and properties (1983), Methods Enzymol., 99, 250-259.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Bos taurus
Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Oryctolagus cuniculus
Catalytic subunit of cAMP-dependent protein kinase and beta Oryctolagus cuniculus
Catalytic subunit of cAMP-dependent protein kinase by phosphorylation of alpha' Bos taurus
Catalytic subunit of cAMP-dependent protein kinase by phosphorylation of alpha' Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015 0.017 phosphorylase b
-
 Oryctolagus cuniculus
0.015 0.017 phosphorylase b bovine heart Bos taurus
0.22
-
 ATP
-
 Oryctolagus cuniculus
0.22
-
 ATP bovine heart Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Oryctolagus cuniculus
Ca2+ requirement Bos taurus
Mg2+ requirement Bos taurus
Mg2+ requirement Oryctolagus cuniculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Bos taurus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
phosphate requirement, phosphate containing enzyme Bos taurus
phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus
phosphate alpha and beta subunits are phosphorylated by protein kinases or autophosphorylation Bos taurus
phosphate alpha and beta subunits are phosphorylated by protein kinases or autophosphorylation Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
heart Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle
-
 Bos taurus
-
cardiac muscle
-
 Oryctolagus cuniculus
-
additional information isozyme distribution in different tissues Bos taurus
-
additional information isozyme distribution in different tissues Oryctolagus cuniculus
-
skeletal muscle
-
 Bos taurus
-
skeletal muscle
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.68
-
-
 Bos taurus
3.68
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphorylase b cosubstrate: Mg-ATP complex Bos taurus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
additional information ITP, and CTP are no substrates Bos taurus ?
-
 ?
additional information ITP, and CTP are no substrates Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
hexadecamer 2 major isozymes in muscle: (alphabetagammadelta)4 and (alpha'betagammadelta)4 Bos taurus
hexadecamer 2 major isozymes in muscle: (alphabetagammadelta)4 and (alpha'betagammadelta)4 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Bos taurus
30
-
 assay at Oryctolagus cuniculus