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Literature summary for 2.7.11.19 extracted from
- Pseudosubstrate-based peptide inhibitors (1991), Methods Enzymol., 201, 287-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LLRDPYALRSVRHLIDNCAFRL | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 336-357 | Homo sapiens |  |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Homo sapiens | |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Mus musculus | |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Oryctolagus cuniculus | |
| VIRDPYALPPLRRLIDAYAFRI | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 333-354 | Mus musculus | |
| VIRDPYALRPLRRLIDAYAFRI | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 332-353 | Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | Oryctolagus cuniculus | - |
ADP + a phosphoprotein | - |
? | |
| ATP + phosphorylase b | Mus musculus | - |
ADP + phosphorylase a | - |
? | |
| ATP + phosphorylase b | Homo sapiens | - |
ADP + phosphorylase a | - |
? | |
| ATP + phosphorylase b | Oryctolagus cuniculus | - |
ADP + phosphorylase a | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Oryctolagus cuniculus | ADP + a phosphoprotein | - |
? | |
| ATP + phosphorylase b | - |
Mus musculus | ADP + phosphorylase a | - |
? | |
| ATP + phosphorylase b | - |
Homo sapiens | ADP + phosphorylase a | - |
? | |
| ATP + phosphorylase b | - |
Oryctolagus cuniculus | ADP + phosphorylase a | - |
? | |
| additional information | substrate specificity | Mus musculus | ? | - |
? | |
| additional information | substrate specificity | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity | Oryctolagus cuniculus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Oryctolagus cuniculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Mus musculus | |
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Homo sapiens | |
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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