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Literature summary for 2.7.11.17 extracted from

  • Fujiwara, Y.; Kawaguchi, Y.; Fujimoto, T.; Kanayama, N.; Magari, M.; Tokumitsu, H.
    Differential AMP-activated protein kinase (AMPK) recognition mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms (2016), J. Biol. Chem., 291, 13802-13808.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GST-tagged wild-type enzyme 1-293 and GST-tagged mutant K49E enzyme 1-293 in Escherichia coli strain JM109 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q63450
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein both wild-type Ca2+/calmodulin-dependent protein kinase kinase isozymes CaMKKalpha and CaMKKbeta, as well as their chimeric mutants, phosphorylate Ca2+/calmodulin-dependent protein kinase Ialpha to the same extent. Subdomain VIII residues Ser357/Leu358 in CaMKKbeta and Ala321/Ile322 in CaMKKalpha confer, at least in part, a distinct substrate recognition of AMPK but not of CaMKIalpha Rattus norvegicus

Synonyms

Synonyms Comment Organism
CaMKIalpha
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Rattus norvegicus