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Literature summary for 2.7.11.17 extracted from

  • Naz, H.; Jameel, E.; Hoda, N.; Shandilya, A.; Khan, P.; Islam, A.; Ahmad, F.; Jayaram, B.; Hassan, M.I.
    Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold (2016), Bioorg. Med. Chem. Lett., 26, 782-788.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-[4-[6-(quinolin-8-yloxy)pyrimidin-4-yl]piperazin-1-yl]benzonitrile
-
 Homo sapiens
3-([6-(quinolin-8-yloxy)pyrimidin-4-yl]oxy)aniline
-
 Homo sapiens
additional information screening of several compounds containing a pyrimidine scaffold against CAMKIV for inhibitory activity against the enzyme, design and synthesis of several inhibitor compounds containing the pyrimidine scaffold, in vitro fluorescence titration, molecular docking calculations under physiological condition and in silico docking studies, cytotoxicity against human cancer cll lines, overview Homo sapiens
N-(4-methoxyphenyl)-6-(piperazin-1-yl)pyrimidin-4-amine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
calcium-calmodulin dependent protein kinase IV
-
 Homo sapiens
CaMKIV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.046
-
 HuH7 cells, Eagle's medium, pH not specified in the publication, 37°C Homo sapiens N-(4-methoxyphenyl)-6-(piperazin-1-yl)pyrimidin-4-amine
0.104
-
 HuH7 cells, Eagle's medium, pH not specified in the publication, 37°C Homo sapiens 2-[4-[6-(quinolin-8-yloxy)pyrimidin-4-yl]piperazin-1-yl]benzonitrile
0.116
-
 HuH7 cells, Eagle's medium, pH not specified in the publication, 37°C Homo sapiens 3-([6-(quinolin-8-yloxy)pyrimidin-4-yl]oxy)aniline

General Information

General Information Comment Organism
evolution the enzyme belongs to the serine/threonine protein kinase family Homo sapiens