Any feedback?
Literature summary for 2.7.11.17 extracted from
- Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II (2011), Arch. Biochem. Biophys., 510, 174-181.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the enzyme can be activated by Ca2+ transients from both extracellular and intracellular sources | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone deacetylase 4 | Rattus norvegicus | the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells | ADP + phosphorylated histone deacetylase 4 | - |
? | |
| ATP + phospholamban | Rattus norvegicus | phosphorylation by CaMKII activates the sarcoplasmic reticulum Ca2+-ATPase, increasing both the rate of Ca2+ clearance from the myoplasm and the frequency of localized Ca2+ release events from intracellular stores | ADP + phosphorylated phospholamban | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone deacetylase 4 | the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells | Rattus norvegicus | ADP + phosphorylated histone deacetylase 4 | - |
? | |
| ATP + phospholamban | - |
Rattus norvegicus | ADP + phosphorylated phospholamban | - |
? | |
| ATP + phospholamban | phosphorylation by CaMKII activates the sarcoplasmic reticulum Ca2+-ATPase, increasing both the rate of Ca2+ clearance from the myoplasm and the frequency of localized Ca2+ release events from intracellular stores | Rattus norvegicus | ADP + phosphorylated phospholamban | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/calmodulin-stimulated protein kinase II | - |
Rattus norvegicus |
| CaMKII | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme appears to moderate gastrointestinal smooth muscle cell excitability. Prolonging the activities of Ca2+-sensitive K+ channels in the plasma membrane of gastrointestinal smooth muscle cells is an important regulatory mechanism carried out by the enzyme. It also may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
