Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Chen, Y.; Luo, F.; Yang, C.; Kirkmire, C.M.; Wang, Z.J.
    Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice (2009), J. Pharmacol. Exp. Ther., 330, 650-659.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Application

Application Comment Organism
medicine blocking CaMKII or CaMKII-mediated signaling may offer a novel therapeutic target for the treatment of neuropathic pain Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-[N-(2-hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine KN93 Mus musculus
Trifluoperazine
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spinal nerve
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Mus musculus
CaMKII
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus spinal nerve L5/L6 ligation, SNL, is found to increase the spinal activity of CaMKII on the ipsilateral side, blocked by KN93 up