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Literature summary for 2.7.11.17 extracted from
- Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission (2006), Proc. Natl. Acad. Sci. USA, 103, 2915-2919.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | required | Mus musculus |  |
| Calmodulin | required | Rattus norvegicus | |
| additional information | brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview | Mus musculus | |
| additional information | brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview | Rattus norvegicus | |
| neurotrophins | have a regulatory role | Mus musculus | |
| neurotrophins | have a regulatory role | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K42M/T286D | inactive CaMKII mutant | Mus musculus |
| K42M/T286D | inactive CaMKII mutant | Rattus norvegicus |
| T286D | constitutively active CaMKII mutant | Mus musculus |
| T286D | constitutively active CaMKII mutant | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | CaMKII isozymes have distinct cellular localizations and function | Mus musculus | - |
- |
| additional information | CaMKII isozymes have distinct cellular localizations and function | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Mus musculus | |
| Ca2+ | required | Rattus norvegicus | |
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | ? | - |
? | |
| additional information | Rattus norvegicus | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
isozymes CaMKII alpha, beta, gamma, and delta | - |
| Rattus norvegicus | - |
isozymes CaMKII alpha, beta, gamma, and delta | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| cardiomyocyte | neonatal and posterior ventricular cardiac myocytes | Mus musculus | - |
| cardiomyocyte | neonatal and posterior ventricular cardiac myocytes | Rattus norvegicus | - |
| myocyte | - |
Mus musculus | - |
| myocyte | - |
Rattus norvegicus | - |
| neuron | neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA | Mus musculus | - |
| neuron | neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA | Rattus norvegicus | - |
| neuron | sympathetic | Mus musculus | - |
| neuron | sympathetic | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | Mus musculus | ? | - |
? | |
| additional information | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcium/calmodulin-dependent protein kinase II | - |
Mus musculus |
| calcium/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
| CaMKII | - |
Mus musculus |
| CaMKII | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Rattus norvegicus | |
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