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Literature summary for 2.7.11.17 extracted from

  • Takemoto-Kimura, S.; Ageta-Ishihara, N.; Nonaka, M.; Adachi-Morishima, A.; Mano, T.; Okamura, M.; Fujii, H.; Fuse, T.; Hoshino, M.; Suzuki, S.; Kojima, M.; Mishina, M.; Okuno, H.; Bito, H.
    Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma (2007), Neuron, 54, 755-770.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant CL3 in COS-7 cells, expression of HA- or GFP-tagged wild-type CL3 in cortical neurons Mus musculus

Protein Variants

Protein Variants Comment Organism
C417S/C419S/C420S/C423S site-directed mutagenesis, mutation of palmitoylation sites Mus musculus
K52A site-directed mutagenesis, inactive mutant, loss-of-function in embryonic cortical neurons elicits a specific impairment in dendrite morphogenesis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
dendrite dendritic raft targeting Mus musculus 30425
-
Golgi membrane anchored, perinuclear Golgi-like membranes Mus musculus 139
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein the enzyme is modified in two sequential lipidification steps, CAAX prenylation followed by kinase-activity-regulated palmitoylation at C417, C419, C420, and C423, the modifications are essential for CL3 membrane anchoring and targeting of the enzyme into detergent-resistant lipid microdomains or rafts in dendrites, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
neuron cortical, expression in developing cortex, dendritic localization Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More multimeric complex formation by CL3 in cortical neurons Mus musculus

Synonyms

Synonyms Comment Organism
CL3
-
 Mus musculus
CLICK-III/CaMKIgamma
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus