Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Ishiguro, K.; Green, T.; Rapley, J.; Wachtel, H.; Giallourakis, C.; Landry, A.; Cao, Z.; Lu, N.; Takafumi, A.; Goto, H.; Daly, M.J.; Xavier, R.J.
    Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation (2006), Mol. Cell. Biol., 26, 5497-5508.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Jurkat cells, co-expression with human CARMA1, T-cell receptor engagement redistributes CaMKII to the immune synapse in an activation-dependent manner Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KN93 binds to the calmodulin-binding site of CaMKII and inhibits its activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information T-cell receptor engagement redistributes CaMKII to the immune synapse, which is interfered by inhibitor KN93, overview Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Blc10 Homo sapiens Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation ADP + phosphorylated Blc10
-
 ?
ATP + CARMA1 Homo sapiens CaMKII is a modulator of CARMA1-mediated NF-kappaB activation, overview ADP + phosphorylated CARMA1
-
 ?
additional information Homo sapiens CaMKII substrates CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes CaMKIIgamma and CaMKIIdelta
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Blc10 activation Homo sapiens ADP + phosphorylated Blc10
-
 ?
ATP + Blc10 Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation Homo sapiens ADP + phosphorylated Blc10
-
 ?
ATP + CARMA1 CaMKII is a modulator of CARMA1-mediated NF-kappaB activation, overview Homo sapiens ADP + phosphorylated CARMA1
-
 ?
ATP + CARMA1 activation by phosphorylation at Ser109, interaction with Bcl10 is facilitated Homo sapiens ADP + phosphorylated CARMA1
-
 ?
additional information CaMKII substrates CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
CaMKII
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens