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Literature summary for 2.7.11.17 extracted from
- A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth (2007), J. Neurosci., 27, 4413-4423.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | dependent on | Rattus norvegicus |  |
| additional information | CaMKI activation by phosphorylation through CaMKK, the CaMK kinase | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-tagged CaMKI in Escherichia coli | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + microtubule affinity regulating kinase 2 | Rattus norvegicus | CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension | ADP + phosphorylated microtubule affinity regulating kinase 2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | CaMKI activation by phosphorylation through CaMKK, the CaMK kinase | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GST-tagged CaMKI from Escherichia coli by glutathione affinity chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression analysis for CaMKI | Rattus norvegicus | - |
| hippocampus | primary cells | Rattus norvegicus | - |
| neuron | hippocampal | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + microtubule affinity regulating kinase 2 | CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension | Rattus norvegicus | ADP + phosphorylated microtubule affinity regulating kinase 2 | - |
? | |
| ATP + microtubule affinity regulating kinase 2 | i.e. MARK2, recombinant myc-tagged MARK2 expressed in HEK-293 cells, mutational determination of phosphorylation sites, overview | Rattus norvegicus | ADP + phosphorylated microtubule affinity regulating kinase 2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcium- and calmodulin-dependent kinase Ialpha | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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