Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transient and stable overexpression of isozyme CaMKIIdelta in rabbit and mouse ventricular myocytes leading to a Ca2+-depdnent shift in voltage dependence of Na+ channel availability, enhanced intermediate inactivation, and slowed recovery from inactivation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic CaMKIIdelta overexpression prolongs QRS duration and repolarization, i.e. QT intervals, decreases effective refractory periods, and increases the propensity to develop ventricular tachyarrhythmia, overview, CaMKIIdelta enhances steady-state inactivation of transgenic rabbit myocyte sodium current INa, steady-state inactivation, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN93 | reversible inhibition of CaMKII | Mus musculus | |
peptide AIP | i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a reversible CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme CaMKIIdelta | Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Na+-channel | Mus musculus | isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview | ADP + phosphorylated Na+-channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
myocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Na+-channel | - |
Mus musculus | ADP + phosphorylated Na+-channel | - |
? | |
ATP + Na+-channel | isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview | Mus musculus | ADP + phosphorylated Na+-channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca2+/calmodulin-dependent protein kinase | - |
Mus musculus |
CaMKII | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |