Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN-93 | - |
Rattus norvegicus | |
additional information | Ca2+ binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions and allowing access to the catalytic site for substrate and ATP | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
sarcoplasmic reticulum | - |
Rattus norvegicus | 16529 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NHE-1 | Rattus norvegicus | phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger | ADP + phosphorylated NHE-1 | - |
? | |
ATP + PLN | Rattus norvegicus | phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition | ADP + phosphorylated PLN | - |
? | |
additional information | Rattus norvegicus | CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NHE-1 | phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger | Rattus norvegicus | ADP + phosphorylated NHE-1 | - |
? | |
ATP + NHE-1 | a Na+-H+-exchanging protein, phosphorylation by CaMKII at the intracellular cytoplasmic domain | Rattus norvegicus | ADP + phosphorylated NHE-1 | - |
? | |
ATP + PLN | phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition | Rattus norvegicus | ADP + phosphorylated PLN | - |
? | |
ATP + PLN | a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17 | Rattus norvegicus | ADP + phosphorylated PLN | - |
? | |
additional information | CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | CaMKII is a multimeric holoenzyme composed of six to twelve subunits encoded by 4 separate genes | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
CaMKII | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |