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Literature summary for 2.7.11.17 extracted from
- Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase Ig in the rat brain (2003), J. Neurochem., 85, 1216-1227.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | dependent on, activates | Rattus norvegicus |  |
| additional information | CaMKIgamma1 is activated by the calmodulin-dependent protein kinase kinase, CaMKK, while CaMKIgamma2 is not | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CaMKIgamma1 and CaMKIgamma2, DNA and amino acid sequence, and genomic structure determination and analysis, expression of FLAG-tagged enzymes in COS_7 cells, hippocampal neurons, and NG108-15 cells in the cytoplasm and neurites, not in the nucleus | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on, activates | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE | Rattus norvegicus |
| 53000 | - |
x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q7TNJ7 | isozyme CaMKIgamma; two alternative splicing isoforms of CaMKIgamma | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | CaMKIgamma1 is activated by the calmodulin-dependent protein kinase kinase, CaMKK, while CaMKIgamma2 is not | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | two alternative splicing isoforms of CaMKIgamma, expression patterns in brain regions, such as the olfactory bulb, hippocampal pyramidal cell layer of CA3, central amygdaloid nuclei, ventromedial hypothalamic nucleus, and pineal gland, overview | Rattus norvegicus | - |
| central amygdaloid nucleus | - |
Rattus norvegicus | - |
| hippocampal pyramidal layer | - |
Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
| olfactory bulb | - |
Rattus norvegicus | - |
| pineal gland | - |
Rattus norvegicus | - |
| ventromedial hypothalamic nucleus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + YLRRRLSDSNF | synapsin site I-derived peptide substrate | Rattus norvegicus | ADP + ? | - |
? | |
| additional information | CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/calmodulin-dependent protein kinase Igamma | - |
Rattus norvegicus |
| Ca2+/calmodulin-dependent protein kinase type IG | - |
Rattus norvegicus |
| CamkG | - |
Rattus norvegicus |
| CaMKI | - |
Rattus norvegicus |
| CaMKIgamma | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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