Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Rattus norvegicus | |
Calmodulin | dependent on | Sus scrofa | |
Calmodulin | dependent on | Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
synapse | dendritic CaMKII is dynamically targeted to the synapse | Rattus norvegicus | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Rattus norvegicus | |
Ca2+ | dependent on | Sus scrofa | |
Ca2+ | dependent on | Xenopus laevis | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Sus scrofa | |
Mg2+ | - |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
additional information | Rattus norvegicus | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
additional information | Sus scrofa | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
additional information | Xenopus laevis | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme CaMKIIalpha | - |
Rattus norvegicus | - |
isozyme CaMKIIalpha | - |
Sus scrofa | - |
isozyme CaMKIIgammaB | - |
Xenopus laevis | - |
isozyme CaMKIIbeta | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Mus musculus |
phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Rattus norvegicus |
phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Sus scrofa |
phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Xenopus laevis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
forebrain | - |
Rattus norvegicus | - |
additional information | CaMKIIalpha is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Mus musculus | ? | - |
? | |
additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Rattus norvegicus | ? | - |
? | |
additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Sus scrofa | ? | - |
? | |
additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Xenopus laevis | ? | - |
? | |
additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Mus musculus | ? | - |
? | |
additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Rattus norvegicus | ? | - |
? | |
additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Sus scrofa | ? | - |
? | |
additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase II | - |
Mus musculus |
calcium/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
calcium/calmodulin-dependent protein kinase II | - |
Sus scrofa |
calcium/calmodulin-dependent protein kinase IIbeta | - |
Xenopus laevis |
CaMKIIalpha | - |
Mus musculus |
CaMKIIalpha | - |
Rattus norvegicus |
CaMKIIbeta | - |
Xenopus laevis |
CaMKIIgammaB | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Rattus norvegicus |
30 | - |
assay at | Sus scrofa |
30 | - |
assay at | Xenopus laevis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
7.5 | - |
assay at | Rattus norvegicus |
7.5 | - |
assay at | Sus scrofa |
7.5 | - |
assay at | Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Sus scrofa | |
ATP | - |
Xenopus laevis |