Literature summary for 2.7.11.17 extracted from

Valverde, R.H.; Tortelote, G.G.; Lemos, T.; Mintz, E.; Vieyra, A.
Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A (2005), J. Biol. Chem., 280, 30611-30618.

Search for more literature for 2.7.11.17

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	dependent on	Electrophorus electricus
additional information	CaM kinase II is activated by phosphorylation through PKA, EC 2.7.11.11	Electrophorus electricus

Inhibitors

Inhibitors	Comment	Organism	Structure
KN-93	specific CaM kinase II inhibitor	Electrophorus electricus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	bound, isolated innervated membranes of electrocytes	Electrophorus electricus	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on, high affinity to	Electrophorus electricus
Mg2+	-	Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Electrophorus electricus	CaM kinase II is strongly phosphorylated by protein kinase A PKA, EC 2.7.11.11, in electrocyte membranes, the activated CaM kinase II 2fold activates the Ca2+ pump and ATPase in the membranes, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Electrophorus electricus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	CaM kinase II is strongly phosphorylated by protein kinase A PKA, EC 2.7.11.11, in electrocyte membranes with simultaneous substantial activation of the Ca2+ pump	Electrophorus electricus

Purification (Commentary)

Purification (Comment)	Organism
partially by preparation of isolated innervated membranes of electrocytes	Electrophorus electricus

Source Tissue

Source Tissue	Comment	Organism	Textmining
electrocyte	-	Electrophorus electricus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	CaM kinase II is strongly phosphorylated by protein kinase A PKA, EC 2.7.11.11, in electrocyte membranes, the activated CaM kinase II 2fold activates the Ca2+ pump and ATPase in the membranes, overview	Electrophorus electricus	?	-	?

Synonyms

Synonyms	Comment	Organism
Ca2+/calmodulin-dependent protein kinase II	-	Electrophorus electricus
CaM kinase II	-	Electrophorus electricus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Electrophorus electricus

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Release 2023.1 (January 2023)