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Literature summary for 2.7.11.17 extracted from

  • Zhang, T.; Brown, J.H.
    Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure (2004), Cardiovasc. Res., 63, 476-486.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Mus musculus
Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Homo sapiens
Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Rattus norvegicus
Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Sus scrofa
Calmodulin dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus
additional information the enzyme is regulated by de-/phosphorylation Mus musculus
additional information the enzyme is regulated by de-/phosphorylation Homo sapiens
additional information the enzyme is regulated by de-/phosphorylation Rattus norvegicus
additional information the enzyme is regulated by de-/phosphorylation Sus scrofa
additional information the enzyme is regulated by de-/phosphorylation Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice overexpressing calmodulin, the mutant mice develop severe cardiac hypertrophy and show increased Ca2+/calmodulin-independent CaMKII activity, overexpression of CaMKIV and CaMKIV knockout also lead to development of cardiac hypertrophy, CaMKIIdeltaB overexpressing transgenic mice do not phosphorylate CREB Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KN-93
-
 Homo sapiens
KN-93
-
 Mus musculus
KN-93
-
 Oryctolagus cuniculus
KN-93
-
 Rattus norvegicus
KN-93
-
 Sus scrofa
additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Homo sapiens
additional information CaMKII possesses an autinhibitory domain, the enzyme is regulated by de-/phosphorylation Mus musculus
additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Oryctolagus cuniculus
additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Rattus norvegicus
additional information CaMKII possesses an autoinhibitory domain, the enzyme is regulated by de-/phosphorylation Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Mus musculus 5737
-
cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Homo sapiens 5737
-
cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Rattus norvegicus 5737
-
cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Sus scrofa 5737
-
cytoplasm isozyme CaMKIIdelta splicing variant deltaC, CaMKIV Oryctolagus cuniculus 5737
-
nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Mus musculus 5634
-
nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Homo sapiens 5634
-
nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Rattus norvegicus 5634
-
nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Sus scrofa 5634
-
nucleus isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly Oryctolagus cuniculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Mus musculus
Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Homo sapiens
Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Rattus norvegicus
Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Sus scrofa
Ca2+ dependent on, Ca2+/calmodulin activate CaMKII prior to autophosphorylation which renders the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cAMP-response element binding protein Rattus norvegicus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein Mus musculus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein Homo sapiens i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein Sus scrofa i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein Oryctolagus cuniculus i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + MEF-2A Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2A
-
 ?
ATP + MEF-2C Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2C
-
 ?
ATP + MEF-2D Mus musculus phosphorylation by CaMKIV ADP + phosphorylated MEF-2D
-
 ?
additional information Mus musculus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
additional information Rattus norvegicus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
additional information Sus scrofa CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
additional information Oryctolagus cuniculus CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?
additional information Homo sapiens CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
Mus musculus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
Oryctolagus cuniculus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
Rattus norvegicus
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-
Sus scrofa
-
 isozyme CaMKIIdelta exists in two splicing variants deltaB and deltaC in the heart
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Homo sapiens
phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Rattus norvegicus
phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Sus scrofa
phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as well as at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Oryctolagus cuniculus
phosphoprotein Ca2+/calmodulin-bound CaMKIIdelta is further activated by autophosphorylation at Thr287beta/gamma and Thr286alpha in the autoinhibitory domain, as wellas at Thr306/Thr307beta/gamma and Thr305/Thr306alpha rendering the enzyme independent of Ca2+/calmodulin Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle
-
 Mus musculus
-
cardiac muscle
-
 Homo sapiens
-
cardiac muscle
-
 Rattus norvegicus
-
cardiac muscle
-
 Sus scrofa
-
cardiac muscle
-
 Oryctolagus cuniculus
-
heart CaMKII, no expression of CaMKIV Mus musculus
-
heart CaMKII, no expression of CaMKIV Homo sapiens
-
heart CaMKII, no expression of CaMKIV Rattus norvegicus
-
heart CaMKII, no expression of CaMKIV Sus scrofa
-
heart CaMKII, no expression of CaMKIV Oryctolagus cuniculus
-
additional information ubiquitous expression of CaMKII Mus musculus
-
additional information ubiquitous expression of CaMKII Homo sapiens
-
additional information ubiquitous expression of CaMKII Rattus norvegicus
-
additional information ubiquitous expression of CaMKII Sus scrofa
-
additional information ubiquitous expression of CaMKII Oryctolagus cuniculus
-
myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Mus musculus
-
myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Homo sapiens
-
myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Rattus norvegicus
-
myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Sus scrofa
-
myocardium isozyme CaMKIIdelta splicing variants deltaB and deltaC Oryctolagus cuniculus
-
neuron CaMKIV Mus musculus
-
neuron CaMKIV Homo sapiens
-
neuron CaMKIV Rattus norvegicus
-
neuron CaMKIV Sus scrofa
-
neuron CaMKIV Oryctolagus cuniculus
-
T-lymphocyte CaMKIV Mus musculus
-
T-lymphocyte CaMKIV Homo sapiens
-
T-lymphocyte CaMKIV Rattus norvegicus
-
T-lymphocyte CaMKIV Sus scrofa
-
T-lymphocyte CaMKIV Oryctolagus cuniculus
-
testis CaMKIV Mus musculus
-
testis CaMKIV Homo sapiens
-
testis CaMKIV Rattus norvegicus
-
testis CaMKIV Sus scrofa
-
testis CaMKIV Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133 Rattus norvegicus ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Mus musculus ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Homo sapiens ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Rattus norvegicus ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Sus scrofa ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + cAMP-response element binding protein i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142 Oryctolagus cuniculus ADP + phosphorylated cAMP-response element binding protein
-
 ?
ATP + MEF-2A phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2A
-
 ?
ATP + MEF-2C phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2C
-
 ?
ATP + MEF-2D phosphorylation by CaMKIV Mus musculus ADP + phosphorylated MEF-2D
-
 ?
additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Mus musculus ?
-
 ?
additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Rattus norvegicus ?
-
 ?
additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Sus scrofa ?
-
 ?
additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Oryctolagus cuniculus ?
-
 ?
additional information CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy, CaMKIIdeltaB expression is increased in heart failure, about 2fold in failing cardiomyopathy, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview Homo sapiens ?
-
 ?
additional information CaMKII is a multifunctional enzyme Mus musculus ?
-
 ?
additional information CaMKII is a multifunctional enzyme Homo sapiens ?
-
 ?
additional information CaMKII is a multifunctional enzyme Rattus norvegicus ?
-
 ?
additional information CaMKII is a multifunctional enzyme Sus scrofa ?
-
 ?
additional information CaMKII is a multifunctional enzyme Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
multimer CaMKII, hetero- or homomultimer Homo sapiens
multimer CaMKII, hetero- or homomultimer Rattus norvegicus
multimer CaMKII, hetero- or homomultimer Sus scrofa
multimer CaMKII, hetero- or homomultimer Oryctolagus cuniculus
multimer CaMKII, hetero-or homonultimer Mus musculus

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Mus musculus
Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
Ca2+/calmodulin-dependent protein kinase II
-
 Sus scrofa
Ca2+/calmodulin-dependent protein kinase II
-
 Oryctolagus cuniculus
CaMKII
-
 Mus musculus
CaMKII
-
 Homo sapiens
CaMKII
-
 Rattus norvegicus
CaMKII
-
 Sus scrofa
CaMKII
-
 Oryctolagus cuniculus
CaMKIV
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus
ATP
-
 Sus scrofa
ATP
-
 Oryctolagus cuniculus