Literature summary for 2.7.11.17 extracted from

Rodriguez-Mora, O.G.; LaHair, M.M.; McCubrey, J.A.; Franklin, R.A.
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells (2005), Cancer Res., 65, 5408-5416.

Search for more literature for 2.7.11.17

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	dependent on, intracellular calcium receptor	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	CaM-KI inhibition by expression of siRNA causes cell cycle arrest in MCF-7 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
KN-93	CaM-KI and CaMKII, CaMKI inhibition in vivo causes cell cycle arrest in MCF-7 cells and reduction in cyclin D1 and Rb protein phosphorylation	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on	Homo sapiens
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	CaM-KI and calcium/calmodulin-dependent kinase kinase CaM-KK participate in the control of cell cycle progression in MCF-7 human breast cancer cells, CaM-KK controls the G0-G1 restriction check point	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14012	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	CaMKI and CaMKII are phosphorylated by the calcium/calmodulin-dependent kinase kinase CaM-KK isozymes, regulatory role, overview	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	differential expression of CaM-KI and CaM-KII in cell lines MCF-7 and MCF-10A	Homo sapiens	-
MCF-10A cell	breast cancer cell line	Homo sapiens	-
MCF-7 cell	breast cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	CaM-KI and calcium/calmodulin-dependent kinase kinase CaM-KK participate in the control of cell cycle progression in MCF-7 human breast cancer cells, CaM-KK controls the G0-G1 restriction check point	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
calcium/calmodulin-dependent kinase I	-	Homo sapiens
CaM-KI	-	Homo sapiens
CaM-KII	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)