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Literature summary for 2.7.11.17 extracted from

  • Haribabu, B.; Hook, S.S.; Selbert, M.A.; Goldstein, E.G.; Tomhave, E.D.; Edelman, A.M.; Snyderman, R.; Means, A.R.
    Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase (1995), EMBO J., 14, 3679-3686.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information CaMKI 1-306, is unable to bind Ca2+-calmodulin and is completely inactive. CaMKI 1-294 does not bind CaM but is fully active in the absence of Ca2+-calmodulin. CaMKI is phosphorylated on Thr177 and its activity enhances approximately 25-fold by CaMKI kinase in a Ca2+-calmodulin dependent manner. CaMKI 1-306 is unresponsive to CaMKI kinase, the 1-294 mutant is phosphorylated and activated by CaMKI kinase in both the presence and absence of Ca(2+)-CaM although at a faster rate in its presence. Replacement of Thr177 with Ala or Asp prevented both phosphorylation and activation by CaMKI kinase and the latter replacement also leads to partial activation in the absence of CaMKI kinase Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme responds directly to Ca2+-calmodulin with increased activity Homo sapiens
Ca2+ Ca2+/calmodulin-dependent Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41340
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14012
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-

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase type I
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 Homo sapiens
CaMKI
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 Homo sapiens