Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | autoinhibitory, in absence of Ca2+/calmodulin the enzyme shows an open conformation with extensive interactions between the C-terminal autoinhibitory sequence and the kinase core influencing the binding site for ATP | Mammalia |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | binding required for activity | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Mammalia | the enzyme phosphorylates e.g. the synaptic vesicle-associated protein synapsin 1 and synapsin 2 | ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Thr177 in the activation segment leads to activation | Mammalia |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | catalytic aspartate residue | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Mammalia | ADP + a phosphoprotein | - |
? | |
ATP + a protein | the enzyme phosphorylates e.g. the synaptic vesicle-associated protein synapsin 1 and synapsin 2 | Mammalia | ADP + a phosphoprotein | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme has an open, active conformation and a closed, inactive conformation | Mammalia |
Synonyms | Comment | Organism |
---|---|---|
CaMKI | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | the ATP-binding site is influenced by the autoinhibitory conformation | Mammalia | |
Calmodulin | binding required for activity | Mammalia |