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Literature summary for 2.7.11.17 extracted from

  • Sturgill, T.W.; Ray, L.B.; Erikson, E.; Maller, J.L.
    Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II (1988), Nature, 334, 715-718.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is supposed to be activated by phosphorylation mediated by insulin Xenopus sp.

Inhibitors

Inhibitors Comment Organism Structure
Phosphatase 2A not phosphatase 1 Xenopus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
Xenopus sp., gel filtration Xenopus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + S6-kinase Xenopus sp. step of a protein kinase cascade initiated by insulin in a yet unidentified manner ?
-
?

Organism

Organism UniProt Comment Textmining
Xenopus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
Xenopus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + S6-kinase step of a protein kinase cascade initiated by insulin in a yet unidentified manner Xenopus sp. ?
-
?
ATP + S6-kinase II phosphorylation sites: serine and threonine Xenopus sp. ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
80
-
2 min, inactivation Xenopus sp.