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Literature summary for 2.7.11.16 extracted from

  • Premont, R.T.; Koch, W.J.; Inglese, J.; Lefkowitz, R.J.
    Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases (1994), J. Biol. Chem., 269, 6832-6841.
    View publication on PubMed
Search for more literature for 2.7.11.16

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane GRK5 protein does not undergo agonist-dependent translocation from cytosol to membranes as do beta-adrenergic receptor kinase and rhodopsin kinase, but rather appears to associate with membranes constitutively Bos taurus 16020
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Organism

Organism UniProt Comment Textmining
Bos taurus P43249
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein major autophosphorylation sites are Ser484 and Thr485 Bos taurus

Purification (Commentary)

Purification (Comment) Organism
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 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain very weak activity Bos taurus
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heart high activity Bos taurus
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kidney very weak activity Bos taurus
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liver very weak activity Bos taurus
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lung high activity Bos taurus
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additional information most abundantly in lung, heart, retina, and lingual epithelium, but expressed very little in brain, liver, kidney, or testis Bos taurus
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retina high activity Bos taurus
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testis very weak activity Bos taurus
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tongue epithelium
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 Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta 2-adrenergic receptor phosphorylation in an agonist-dependent manner, phosphorylates the C-terminal tail regions of both receptor proteins Bos taurus ADP + phosphorylated beta 2-adrenergic receptor
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 ?
ATP + protein major autophosphorylation sites are Ser484 and Thr485 Bos taurus ADP + phosphoprotein
-
 ?
ATP + rhodopsin GRK5 phosphorylates rhodopsin in a light-dependent manner, phosphorylates the C-terminal tail region Bos taurus ADP + phosphorylated rhodopsin
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase GRK5
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 Bos taurus
GRK5
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 Bos taurus