Literature summary for 2.7.11.15 extracted from

Rivas, V.; Carmona, R.; Munoz-Chapuli, R.; Mendiola, M.; Nogues, L.; Reglero, C.; Miguel-Martin, M.; Garcia-Escudero, R.; Dorn, G.W.; Hardisson, D.; Mayor, F.; Penela, P.
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 (2013), J. Clin. Invest., 123, 4714-4730.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [beta-adrenergic receptor]	Mus musculus	-	ADP + phospho-[beta-adrenergic receptor]	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [beta-adrenergic receptor]	-	Mus musculus	ADP + phospho-[beta-adrenergic receptor]	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 2	-	Mus musculus
GRK2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	enzyme ablation leads to marked vascular malformations involving impaired recruitment of mural cells. Enzyme downregulation is a relevant event in the tumoral angiogenic switch	Mus musculus
physiological function	G protein-coupled receptor kinase 2 is a key angiogenesis regulator	Mus musculus

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Release 2023.1 (January 2023)