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Literature summary for 2.7.11.15 extracted from

  • Garcia-Guerra, L.; Nieto-Vazquez, I.; Vila-Bedmar, R.; Jurado-Pueyo, M.; Zalba, G.; Diez, J.; Murga, C.; Fernandez-Veledo, S.; Mayor, F.; Lorenzo, M.
    G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity (2010), Diabetes, 59, 2407-2417.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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 Mus musculus
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myoblast
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 Mus musculus
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Synonyms

Synonyms Comment Organism
GRK2
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus GRK2 protein expression is enhanced under insulin-resistant conditions up

General Information

General Information Comment Organism
malfunction the influence of GRK2 levels is investigated in insulin signaling in myoblasts and adipocytes with experimentally increased or silenced levels of GRK2, as well as in GRK2 hemizygous animals expressing 50% lower levels of this kinase in three different models of insulin resistance: TNF-alpha infusion, aging, and high-fat diet (HFD). GRK2 levels are increased by 2fold in muscle and adipose tissue in the animal models tested. In contrast, hemizygous GRK2 mice show enhanced insulin sensitivity and do not develop insulin resistance by TNF-alpha, aging, or high-fat diet. Reduced GRK2 levels induce a lean phenotype and decrease age-related adiposity Mus musculus
physiological function insulin signaling is regulated by GRK2 levels in adipocytes and myocytes Mus musculus