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Literature summary for 2.7.11.15 extracted from

  • Kahsai, A.; Zhu, S.; Fenteany, G.
    G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells (2010), Biochim. Biophys. Acta, 1803, 300-310.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.15

Protein Variants

Protein Variants Comment Organism
K220R kinase-dead mutant shows no phosphorylation of ezrin/radixin/moesin (ERM) proteins Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ezrin + ATP Homo sapiens
-
 phosphorylated ezrin + ADP
-
 ?
moesin + ATP Homo sapiens
-
 phosphorylated moesin + ADP
-
 ?
radixin + ATP Homo sapiens
-
 phosphorylated radixin + ADP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDCK cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ezrin + ATP
-
 Homo sapiens phosphorylated ezrin + ADP
-
 ?
moesin + ATP
-
 Homo sapiens phosphorylated moesin + ADP
-
 ?
radixin + ATP
-
 Homo sapiens phosphorylated radixin + ADP
-
 ?

Synonyms

Synonyms Comment Organism
GRK2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function GRK2 regulates membrane protrusion and collective migration of a cell sheet during wound closure in MDCK cell monolayers at least partly through phosphorylation of ezrin/radixin/moesin (ERM) proteins, in particular radixin Homo sapiens