Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic mice with cardiac-restricted expression of a competitive inhibitor of GRK3, i.e. the carboxyl-terminal plasma membrane targeting domain of GRK3 from Rattus norvegicus, show significantly enhanced agonist-stimulated beta1-adrenergic receptor-mediated activation of ERK1/2, but no alterations of cardiac mass or left ventricular dimensions, versus cardiac myocytes from nontransgenic littermate control mice consistent with inhibition of GRK3, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | GRK2 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain, overview | ? | - |
? | |
additional information | Mus musculus | GRK3 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by its carboxyl-terminal pleckstrin homology domain. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness, distinct functions of GRK3 in regulation of cardiac contractility and growth, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C56BL/6-CBA hybrid mice | - |
Mus musculus | - |
GRK2; C56BL/6-CBA hybrid mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | GRK2 | Mus musculus | - |
cardiac myocyte | GRK3 | Mus musculus | - |
heart | distribution of GRK2 in mouse myocardial tissue, overview | Mus musculus | - |
heart | distribution of GRK3 in mouse myocardial tissue, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GRK2 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain, overview | Mus musculus | ? | - |
? | |
additional information | GRK3 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by its carboxyl-terminal pleckstrin homology domain. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness, distinct functions of GRK3 in regulation of cardiac contractility and growth, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GRK2 | - |
Mus musculus |
GRK3 | - |
Mus musculus |