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Literature summary for 2.7.11.15 extracted from

  • Molnar, C.; Holguin, H.; Mayor, F.; Ruiz-Gomez, A.; de Celis, J.F.
    The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila (2007), Proc. Natl. Acad. Sci. USA, 104, 7963-7968.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of GRK2-fusion constructs in transgenic flies, expression analysis, overview Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information lowering Gprk2 levels in the wing disc reduces the expression of Smo targets and causes a phenotype reminiscent of loss of Smo function, phenotype, overview Drosophila melanogaster
additional information generation of a Gprk2 deficiency, phenotype, overview Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Drosophila melanogaster 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smo Drosophila melanogaster GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview ADP + phosphorylated Smo
-
 ?
additional information Drosophila melanogaster Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
 gene Gprk2
-
Drosophila melanogaster P32866
-
-

Source Tissue

Source Tissue Comment Organism Textmining
S2 cell
-
 Drosophila melanogaster
-
wing
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smo
-
 Drosophila melanogaster ADP + phosphorylated Smo
-
 ?
ATP + Smo GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview Drosophila melanogaster ADP + phosphorylated Smo
-
 ?
additional information Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor regulatory kinase
-
 Drosophila melanogaster
G protein-coupled receptor regulatory kinase 2
-
 Drosophila melanogaster
Gprk2
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster