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Literature summary for 2.7.11.15 extracted from

  • Takahashi, M.; Uchikado, H.; Caprotti, D.; Weidenheim, K.M.; Dickson, D.W.; Ksiezak-Reding, H.; Pasinetti, G.M.
    Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles (2006), J. Neuropathol. Exp. Neurol., 65, 1157-1169.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + alpha-synuclein Homo sapiens colocalization of GRK2, GRK5, alpha-synuclein, and tau in neurodegenerative disorders characterized by fibrillary tau inclusions and/or alpha-synuclein-enriched Lewy bodies, overview ADP + phosphorylated alpha-synuclein
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 ?
additional information Homo sapiens GPCR-dependent kinases play a major role in agonist-induced phosphorylation and desensitization of G-protein coupled receptors, GRK2 is a component of neuronal and glial fibrillary tau deposits with no preference in tau isoform binding, GRK2 may play a role in hyperphosphorylation of tau in tauopathies ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain 40-50% co-localization of GRK2 with neurofibrillary tangles in Alzheimer's disease Homo sapiens
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additional information Lewy bodies were negative for both GRK2 and GRK5 in Lewy body disease Homo sapiens
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neuron colocalization of GRK2 and tau in intracellular neurofibrillary tangles and isolated paired helical filaments Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha-synuclein colocalization of GRK2, GRK5, alpha-synuclein, and tau in neurodegenerative disorders characterized by fibrillary tau inclusions and/or alpha-synuclein-enriched Lewy bodies, overview Homo sapiens ADP + phosphorylated alpha-synuclein
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 ?
ATP + alpha-synuclein phosphorylation at Ser129 Homo sapiens ADP + phosphorylated alpha-synuclein
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 ?
additional information GPCR-dependent kinases play a major role in agonist-induced phosphorylation and desensitization of G-protein coupled receptors, GRK2 is a component of neuronal and glial fibrillary tau deposits with no preference in tau isoform binding, GRK2 may play a role in hyperphosphorylation of tau in tauopathies Homo sapiens ?
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 ?
additional information GRK2 and tau do not crossreact Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
G-protein coupled receptor kinase 2
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 Homo sapiens
GRK2
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 Homo sapiens
More the enzyme belongs to the serine/threonine kinase family Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens