Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.15 extracted from

  • Shahid, G.; Hussain, T.
    GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells (2007), J. Biol. Chem., 282, 20612-20620.
    View publication on PubMed
Search for more literature for 2.7.11.15

Activating Compound

Activating Compound Comment Organism Structure
Insulin initiates GRK2 membrane translocation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of GRK2-deficient cells by expression of siRNA leads to increased insulin-induced glycogen synthesis and basal and insulin-stimulated phosphorylation of Ser21 in glycogen synthase kinase-3'alpha, phosphorylation of insulin receptor substrate 1 ia increased in case of GRK2 depletion Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol GRK2 translocation from cytosol to the plasma membrane Mus musculus 5829
-
membrane GRK2 membrane translocation is induced by insulin Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + insulin receptor substrate 1 Mus musculus role of GRK2 in insulin receptor IR signaling ADP + phosphorylated insulin receptor substrate 1
-
 ?
additional information Mus musculus GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells, regulates basal and insulin-stimulated glycogen synthesis via a post-IR signaling mechanism, and GRK2 may contribute to reduced IR expression and function during chronic insulin exposure ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
FL83B cell a hepatocyte cell line Mus musculus
-
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + insulin receptor substrate 1 role of GRK2 in insulin receptor IR signaling Mus musculus ADP + phosphorylated insulin receptor substrate 1
-
 ?
ATP + insulin receptor substrate 1 phosphorylation at Ser307 by GRK2 Mus musculus ADP + phosphorylated insulin receptor substrate 1
-
 ?
additional information GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells, regulates basal and insulin-stimulated glycogen synthesis via a post-IR signaling mechanism, and GRK2 may contribute to reduced IR expression and function during chronic insulin exposure Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
G-protein-coupled receptor kinase 2
-
 Mus musculus
GPCR kinase 2
-
 Mus musculus
GRK2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus