Literature summary for 2.7.11.15 extracted from

Whalen, E.J.; Foster, M.W.; Matsumoto, A.; Ozawa, K.; Violin, J.D.; Que, L.G.; Nelson, C.D.; Benhar, M.; Keys, J.R.; Rockman, H.A.; Koch, W.J.; Daaka, Y.; Lefkowitz, R.J.; Stamler, J.S.
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2 (2007), Cell, 129, 511-522.

Search for more literature for 2.7.11.15

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay	Homo sapiens
additional information	quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay	Mus musculus
nitric oxide	inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation	Homo sapiens
nitric oxide	inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation	Mus musculus
S-nitrosothiols	inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation	Homo sapiens
S-nitrosothiols	inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Mus musculus	16020	-
membrane	-	Homo sapiens	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Mus musculus
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + beta-adrenergic receptor	Mus musculus	the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + beta-adrenergic receptor	Homo sapiens	the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + rhodopsin	Mus musculus	-	ADP + phosphorylated rhodopsin	-	?
ATP + rhodopsin	Homo sapiens	-	ADP + phosphorylated rhodopsin	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
lung	-	Mus musculus	-
U2-OS cell	an osteosarcoma cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta-adrenergic receptor	the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview	Mus musculus	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + beta-adrenergic receptor	the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview	Homo sapiens	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + beta-adrenergic receptor	mapping of S-nitrosylation sites and regulatory locus in GRK2	Mus musculus	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + beta-adrenergic receptor	recombinantly expressed beta-adrenergic receptor in U2-OS cells, mapping of S-nitrosylation sites and regulatory locus in GRK2	Homo sapiens	ADP + phosphorylated beta-adrenergic receptor	-	?
ATP + rhodopsin	-	Mus musculus	ADP + phosphorylated rhodopsin	-	?
ATP + rhodopsin	-	Homo sapiens	ADP + phosphorylated rhodopsin	-	?

Synonyms

Synonyms	Comment	Organism
G-protein-coupled receptor kinase 2	-	Mus musculus
G-protein-coupled receptor kinase 2	-	Homo sapiens
GRK2	-	Mus musculus
GRK2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus
ATP	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)