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Literature summary for 2.7.11.15 extracted from
- Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2 (2005), J. Biol. Chem., 280, 11052-11058.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| alpha2A-adrenergic receptor | epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GRK2 in Spodoptera frugiperda Sf9 cells using the baculovirus infection system | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Bos taurus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Bos taurus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha2A-adrenergic receptor | Bos taurus | - |
ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
| ATP + G protein-coupled receptor | Bos taurus | desensitization of agonist-activated receptor | ADP + phosphorylated G protein-coupled receptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction and phosphorylation activity utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| central nervous system | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha2A-adrenergic receptor | - |
Bos taurus | ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
| ATP + alpha2A-adrenergic receptor | interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction and phosphorylation activity utilizing recombinant GST-tagged wild-type and several mutant alpha2A AR substrates, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus | ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
| ATP + G protein-coupled receptor | - |
Bos taurus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
| ATP + G protein-coupled receptor | desensitization of agonist-activated receptor | Bos taurus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase 2 | - |
Bos taurus |
| GRK2 | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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