Literature summary for 2.7.11.15 extracted from

Williams, M.L.; Hata, J.A.; Schroder, J.; Rampersaud, E.; Petrofski, J.; Jakoi, A.; Milano, C.A.; Koch, W.J.
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts (2004), Circulation, 109, 1590-1593.

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Cloned(Commentary)

Cloned (Comment)	Organism
adenovirus-mediated gene transfer and expression of inhibitor betaARKct in primary myocytes isolated from hearts of patients in the end-stage of heart failure undergoing heart transplantation, betaARK1 activity is inhibited but beta-adrenergic signaling and contractile function are improved	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
betaARKct	the isolated C-terminal sequence of the enzyme acts as a peptide inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	betaARK1 inhibition improves beta-adrenergic signaling and contractile function in failing human myocytes	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Homo sapiens	-
myocardium	-	Homo sapiens	-
myocyte	primary isolated from hearts of patients in the end-stage of heart failure undergoing heart transplantation	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	betaARK1 inhibition improves beta-adrenergic signaling and contractile function in failing human myocytes	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
beta-adrenergic receptor kinase	-	Homo sapiens
betaARK1	-	Homo sapiens

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Release 2023.1 (January 2023)