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Literature summary for 2.7.11.15 extracted from

  • Goldman, P.S.; DeMaggio, A.J.; Hoekstra, M.F.; Goodman, R.H.
    The beta-adrenergic receptor kinase interacts with the amino terminus of the G protein beta subunit (1997), Biochem. Biophys. Res. Commun., 240, 425-429.
    View publication on PubMed
Search for more literature for 2.7.11.15

Activating Compound

Activating Compound Comment Organism Structure
G protein betagamma-subunit activates, binding domain is localized to the C-terminal region of beta-ARK Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
beta-ARK 1 is cloned and expressed in yeast strain L40 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm predominantly cytoplasmic, enzyme activity depends upon its translocation from the cytoplasm to the membrane, the betagamma subunits of G proteins bind to enzyme and recruit it to the membrane, beta-ARK 1 binds to Gbeta2 Bos taurus 5737
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membrane enzyme activity depends upon its translocation from the cytoplasm to the membrane, the betagamma subunits of G proteins bind to enzyme and recruit it to the membrane, beta-ARK 1 binds to Gbeta2 Bos taurus 16020
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Organism

Organism UniProt Comment Textmining
Bos taurus
-
 beta-ARK 1
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Bos taurus
-
 enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor
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 Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus